Comparison of Dissolution Properties of Piroxicam Using Microcrystalline Cellulose and a New Excipient (LoxOralTM)

Introduction: During the last decade, the trend in drug discovery has increased the number of active pharmaceutical ingredients (APIs) that exhibit high lipophilicity and poor water solubility, also associated with poor dissolution characteristics (Vogt et al., 2008). Dissolution rate in the gastrointestinal tract is the rate limiting factor for the absorption of many of these drugs, which therefore suffer from poor oral bioavailability (Zimmermann et al., 2009).